Both are amino acids that your body uses to produce nitric oxide, but they work differently. L-arginine is the direct precursor—your body converts it straight into NO.

However, when you take L-arginine orally, much of it gets broken down in your digestive system before reaching your blood.

L-citrulline converts into L-arginine in your kidneys and isn't broken down as much during digestion, so it actually raises blood arginine levels more effectively.

This formula includes both because they work synergistically—the combination is more effective than either one alone at increasing and sustaining NO levels.

For athletic performance, take 30-60 minutes before your workout to maximize blood flow and oxygen delivery to muscles during exercise.
For general cardiovascular support, you can take it any time of day with or without food. Some people split their dose, taking half in the morning and half before evening exercise.
Consistency is key—regular daily use provides the best results for cardiovascular health and circulation support.

Absolutely! Using them together is highly recommended. Test your NO levels first thing in the morning to establish your baseline, then take NOx Synergy™ and test again 1-2 hours later to see how your body responds.
This helps you track whether the formula is effectively supporting your NO production and allows you to adjust timing or dosage based on your individual results.
Many practitioners recommend this combined approach for optimal NO optimization.

People with low blood pressure, those taking blood pressure medications, or anyone taking nitrate medications (like nitroglycerin) should consult their healthcare provider before use, as NO can lower blood pressure.
People with a history of heart attack, herpes outbreaks, kidney disease, or the rare genetic condition GAMT deficiency should also consult their doctor.
Always stop taking this supplement at least 2 weeks before any scheduled surgery.
If you're pregnant, nursing, or taking any medications, consult your healthcare provider first.