Description
Description
Homocysteine Supreme by Designs for Health is a targeted methylation formula that supports healthy homocysteine metabolism, cardiovascular health and cognitive function.
It provides vitamins B2, B6, folate (as Quatrefolic® 5-MTHF) and B12 (as MecobalActive® methylcobalamin) in their active forms, so the body can use them directly without conversion.
This is especially valuable for people with MTHFR or other methylation gene variants.
The formula also includes 900 mg of TMG, a second methyl donor that recycles homocysteine through a folate-independent pathway, plus L-serine to support the conversion of homocysteine into cysteine, a building block of glutathione.
Gluten free, dairy free, soy free, vegetarian and non-GMO.
How to use
How to use
Take 2 capsules per day with meals, or as directed by your health-care practitioner.
Taking it with food supports comfort and absorption, and splitting the dose between two meals is a common practitioner approach.
Because B vitamins and methyl donors affect individual pathways differently, especially in people with MTHFR or other methylation gene variants, it's best used with a practitioner who can track homocysteine levels over time.
Ingredients
Ingredients
Riboflavin (as Riboflavin-5-Phosphate) 30 mg, Vitamin B6 (as Pyridoxal-5-Phosphate) 10 mg, Folate (as Quatrefolic® (6S)-5-methyltetrahydrofolate, glucosamine salt) 3400 mcg DFE, Vitamin B12 (as MecobalActive® Methylcobalamin) 1000 mcg, Trimethylglycine (TMG) 900 mg, L-Serine 100 mg
Other ingredients: Cellulose (capsule), microcrystalline cellulose, ascorbyl palmitate, dicalcium phosphate, silicon dioxide.
Homocysteine Supreme
Bioactive B2, B6, Quatrefolic® folate, methyl B12 and 900 mg TMG to support healthy homocysteine metabolism, methylation, heart and brain health.
- Supports Healthy Homocysteine Metabolism
- Dual-Pathway Methylation Support
- Cardiovascular & Vascular Health
- Brain & Cognitive Function
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Description
Description
Homocysteine Supreme by Designs for Health is a targeted methylation formula that supports healthy homocysteine metabolism, cardiovascular health and cognitive function.
It provides vitamins B2, B6, folate (as Quatrefolic® 5-MTHF) and B12 (as MecobalActive® methylcobalamin) in their active forms, so the body can use them directly without conversion.
This is especially valuable for people with MTHFR or other methylation gene variants.
The formula also includes 900 mg of TMG, a second methyl donor that recycles homocysteine through a folate-independent pathway, plus L-serine to support the conversion of homocysteine into cysteine, a building block of glutathione.
Gluten free, dairy free, soy free, vegetarian and non-GMO.
How to use
How to use
Take 2 capsules per day with meals, or as directed by your health-care practitioner.
Taking it with food supports comfort and absorption, and splitting the dose between two meals is a common practitioner approach.
Because B vitamins and methyl donors affect individual pathways differently, especially in people with MTHFR or other methylation gene variants, it's best used with a practitioner who can track homocysteine levels over time.
Ingredients
Ingredients
Riboflavin (as Riboflavin-5-Phosphate) 30 mg, Vitamin B6 (as Pyridoxal-5-Phosphate) 10 mg, Folate (as Quatrefolic® (6S)-5-methyltetrahydrofolate, glucosamine salt) 3400 mcg DFE, Vitamin B12 (as MecobalActive® Methylcobalamin) 1000 mcg, Trimethylglycine (TMG) 900 mg, L-Serine 100 mg
Other ingredients: Cellulose (capsule), microcrystalline cellulose, ascorbyl palmitate, dicalcium phosphate, silicon dioxide.

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Homocysteine Supreme
Frequently Asked Questions
What is Homocysteine Supreme and what does it do?
Homocysteine Supreme by Designs for Health is a targeted methylation formula that supports healthy homocysteine metabolism.
It combines active forms of vitamins B2, B6, folate (as Quatrefolic® 5-MTHF) and B12 (as MecobalActive® methylcobalamin) with TMG and L-serine.
Together, these nutrients help the body recycle homocysteine into methionine or convert it into cysteine, supporting heart, brain and overall cellular health.
How do I take Homocysteine Supreme?
Take 2 capsules of Homocysteine Supreme per day with meals, or as directed by your health-care practitioner.
Your practitioner may adjust the amount based on your needs and may suggest checking homocysteine levels over time to track your progress.
Who might benefit from Homocysteine Supreme?
Homocysteine Supreme is a good fit for people who want focused support for methylation, cardiovascular health and cognitive function.
It may especially suit those with MTHFR or other gene variants that affect B-vitamin metabolism, people with low B-vitamin intake, and anyone who prefers bioactive vitamin forms that need no conversion in the body.
How is Homocysteine Supreme different from a regular B-complex?
A standard B-complex like B-Supreme provides all eight B vitamins for broad energy and cellular support.
Homocysteine Supreme focuses only on the nutrients that drive the homocysteine pathway, in their active forms, with 900 mg of TMG as an extra methyl donor.
This gives more targeted support for methylation and heart health.
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