Alpha-Ketoglutarate mse® is a targeted mitochondrial-support formula built around calcium alpha-ketoglutarate (Ca-AKG), a stabilized salt form of alpha-ketoglutarate (AKG) — a natural intermediate of the Krebs cycle that the body relies on for cellular energy production but which declines significantly with age.

AKG plays a central role in bioenergetics: it helps stabilize Krebs cycle flux, supports ATP generation and fat oxidation, and assists in converting metabolic byproducts like ammonia into forms the body can safely eliminate. It also acts as a cofactor for TET and JMJD enzymes involved in epigenetic (DNA/histone) regulation, which is the basis for its growing reputation in longevity science. A retrospective clinical study following 42 adults over an average of 7 months found that Ca-AKG-based supplementation was associated with an average 8-year reduction in biological age, as measured by DNA methylation testing — a finding that has since been supported by controlled research into AKG's role in cellular energy metabolism, epigenetic regulation, and healthy aging. 

The added calcium supports the electrical and structural functions calcium is known for — nerve signal transmission, bone and dental mineralization, and cardiac and skeletal muscle contraction — while Ca-AKG's dual nature helps stabilize the body's intracellular signaling environment.

This product is developed under the MitoMed® concept, created by Dr. Franz Enzmann, founder of mse Pharmazeutika and the International Mitochondrial Medicine Association (IMMA). The MitoMed concept is built on nearly 30 years of research into mitochondria — the "power plants" of our cells — and uses targeted, single-ingredient formulas called Mitoceuticals® that can be combined and dosed individually according to personal need. Products are manufactured in Germany with a focus on high-purity, naturally occurring compounds and minimal additives