Calcium alpha-ketoglutarate (Ca-AKG) is a naturally-occurring metabolite that's essential for the Krebs cycle—the process your cells use to convert food into energy (ATP).

It also regulates DNA methylation, supports autophagy (cellular cleanup), and provides building blocks for important molecules like glutathione and collagen.

The problem is that AKG levels drop dramatically as you age, declining nearly 90% between ages 40 and 80.

This decline contributes to decreased energy, reduced cellular repair, and accelerated aging.

Since AKG isn't found in foods, supplementation is the only way to restore youthful levels.

Biological age measures how old your cells actually are based on DNA methylation patterns, which is different from your chronological age (how many birthdays you've had).

In a published 2021 clinical study, 42 people taking 1000mg of calcium AKG daily for an average of 7 months showed their biological age decreased by an average of 8 years when measured using the TruAge DNA methylation test.

This means their cells were functioning like they were 8 years younger.

You can track this yourself using at-home biological age testing kits before and after supplementing for 6-10 months.

The landmark clinical study showed significant biological age reversal after an average of 7 months of daily use at 1000mg.

Animal studies suggest benefits like increased lifespan and reduced frailty become apparent when supplementation begins in midlife and continues long-term.

For longevity benefits, think of Ca-AKG as a daily practice rather than a short-term intervention—consistent use for at least 6-12 months is recommended to see measurable changes in biological age testing and experience improvements in energy, vitality, and age-related health markers.

Calcium AKG has GRAS (Generally Recognized As Safe) status and clinical research shows no significant adverse effects even at doses up to 4.5 grams daily for as long as 3 years.

The 1000mg dose in this formula matches what was safely used in the biological age reversal study.

Because it's a naturally-occurring metabolite your body already produces, it's generally well-tolerated.

As with any supplement, consult your healthcare provider before starting, especially if you have kidney issues, take medications, or are pregnant or nursing.