Both NR (nicotinamide riboside) and NMN are NAD+ precursors, but NR is converted to NAD+ through a more direct pathway requiring less ATP.
NR has more published human clinical studies demonstrating safety and effectiveness. Both compounds effectively raise NAD+ levels, so the choice often comes down to personal preference, though NR may be more stable and bioavailable in supplement form.

Pterostilbene and NR work synergistically for optimal longevity benefits. NR increases NAD+ levels (the fuel), while pterostilbene activates sirtuins (the longevity genes that use NAD+ as fuel).
This creates a powerful combination where each compound enhances the other's effectiveness. Pterostilbene also provides additional antioxidant and anti-inflammatory benefits that complement NR's cellular energy support.

NAD+ levels can increase within 2 weeks of consistent supplementation, though you may not feel dramatic changes immediately since this works at the cellular level.
Many people report increased energy and mental clarity within 2-4 weeks.
Benefits for cardiovascular health, metabolic function, and anti-aging effects accumulate over months of consistent use. Think of this as a long-term investment in your cellular health rather than a quick fix.

Yes, this formula pairs well with other longevity supplements. It's commonly stacked with trans-resveratrol for additional sirtuin activation, TMG (trimethylglycine) to support methylation pathways, or omega-3s for overall health.
In fact, NR and resveratrol/pterostilbene are designed to work together.
Always consult your healthcare provider if you're on medications or have health conditions.